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Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 47 Issue 1 (2020). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.
Original Research
Effect of oxyprogesterone caproate, tamoxif en and their combination on the level of steroid hormone receptors in the tumor, and some paran1eters of the reproductive system in patients with endometrial cancer
A. S. Vishnevsky1, J. A. Shtofmakher1, J. V. Bokhman1, E. V. Tsyrlina1, J. F. Bobrov1, O. F. Chepick1, D. F. Sofroniy1
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1
Petrov Research Institute of Oncologoy, Leningrad (USSR)
Clin. Exp. Obstet. Gynecol. 1990, 17(3-4), 159–162;
Published: 10 September 1990
Abstract
The results of preoperative use of oxyprogesterone caproate (OPC), Tamoxifen and their combination in 165 patients suffering from primary endometrial carcinoma are presented. It was shown that Tamoxifen was able to increase concentrations cytoplasmatic receptors to progesterone in the tumor. The incidence of specific hormonal pathomorphosis in the tissue of the tumor in patients who received a combination of OPC and Tamoxifen was significantly higher (80% of cases) as compared to the separate use of OPC (60%) or Tamoxifen (57%).