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Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 47 Issue 1 (2020). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.
Case Report
Vulvo-vaginal condylomatosis and relapse: combined treatment with electrocauterization and beta-interferon
R. Piccoli1, M. G. Santoro1, C. Nappi1, M. Capodanno1, V. De Santis1, P. C. La Torre2, S. Costa3, U. Montemagno1
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1
Department of Gynaecology Obstetrics and Physiopathology of Human Reproduction II Faculty of Medicine and Surgery - University of Naples (Italy)
2
Clinical Pharmacology Dept. “Serono” - Roma (Italy)
3
S. “Orsola Hospital” - II Department of Obstetrics and Gynaecology Faculty of Medicine and Surgery - University of Bologna (Italy)
Clin. Exp. Obstet. Gynecol. 1989, 16(1), 30–35;
Published: 10 March 1989
Abstract
The therapeutical effectiveness of. beta-interferon and the possibility of reducing the incidence of relapses were evaluated by selecting three groups of patients affected with three forms of condylomatosis and submitting then to various treatments. In the first group of sixty patients treated with beta-interferon, we obtained the best results in micro-condylomatosis (a 100% response), while florid condylomatosis responded less well to the treatment (72% with no response). In the second group of ten patients, electrocoagulation of florid condylomata determined a complete response (CR) in seven. cases (70%). Moreover, immunoperoxidase identified threcase of sub-clinical infection, two of which relapsed. In the third group of ten patients, we combined electrocoagulation with beta-interferon. This combination showed the effectiveness of beta-interferon in decreasing relapses. This result is evident if we consider that only one out of four patients with immunopelmmunoperoxlctase-positive biopsy relapsed. HPV = Human Papillomavirus; IFN = Interferon; CR= Complete response; PR= Partial response; AR= Absence of response; DTC = Diathermocoagulation.