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Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 47 Issue 1 (2020). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.
Case Report
5-(2-bromoethyl)-2’-deoxyuridine: a selective inhibitor of herpes simplex viruses in vitro
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Institute of Clinical Obstetrics and Gynecology, University of Cagliari (Italy)
Clin. Exp. Obstet. Gynecol. 1989, 16(1), 16–20;
Published: 10 March 1989
Abstract
A new pyrimidine analog: 5-（2-bromoethyl)－2 ’－deoxyuridine (BEUdR)， was tested in vitro for antiviral activity on Herpes simplex virus types 1 and 2. As reference compounds, ACG, BVUdR and PAA were used. Compared to ACG and BVUdR, BEUdR resulted less potent on both HSV-1 and HSV-2. However, a 50% inhibition of the multiplication of uninfected cells could be obtained only at very high BEUdR concentration (ID50 = 8500 μM). This makes BEUdR the least toxic analog known and gives it a selective index comparable to, if not better, than of ACG and BVUdR.