The Authors evaluate the efficacy of the intravenous infusion of PGF2 alpha in the induction of abortion in the second trimester of pregnancy with live fetus (Italian Law no. 194/1978). Abortion occurred in 3 out of 11 (27.27%) nulliparous patients, and uterine curettage was necessary in 2 cases. The interval between administration of the drug and the beginning of uterine contractions was 31.42 ± 14.15 minutes (range 10 to 35 minutes), the duration of infusion was 7.55 ± 3.64 hours (range 7 to 9.15 hours), the interval between initiation of infusion and delivery was 8.10 ± 2.60 hours (range 7 to 9.45 hours), and the dose administered was 20.23 ± 3.75 mg (range 15 to 25 mg). Side effects were reported in 10 cases (90.90%), and in 5 cases these effects were caused by interruption of infusion. Abortion occurred in 7 out of 13 pluriparous patients (53.84%), and uterine curettage was necessary in 4 cases. The interval between administration of the drug and the beginning of uterine contractions was 20 ± 12.24 minutes (range 20 to 45 minutes), the duration of infusion was 8.26 ± 0.9 hours (range 3.10 to 16 hours), the interval between initiation of infusion and delivery was 8.40 ± 0.8 hours (range 3.0 to 9.6 hours), and the dose administered was 19.28 ± 5.34 mg (range 5 to 25 mg). Side effects were reported in 11 cases (84.61%), and in 6 cases these effects were caused by interruption of infusion.