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Case Report
Estradiol and progesterone binding in uterine leiomyomata and pregnant myometrium
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1
Institute of Obstetrics and Gynaecology - University of Padua (Italy)
Clin. Exp. Obstet. Gynecol. 1987, 14(3-4), 155–160;
Published: 10 September 1987
Abstract
In order to verify the endogenous steroid influences on the myometrium: we com-pared the receptor status in 18 specimens of uterine leiomyomata and 31 specimens of pregnant myometrium. 17-ß-Estradiol and Progesterone receptors were assayed in the cytosol and nuclear extracts. In the uterine leiomyomata we observed the following mean values: PgR/c 279 fmol/mg, PgR/n 89 fmol/mg, ER/c 52.5 fmol/mg, ER/n 12.3 fmol/mg. In the pregnant myometrium we observed the following mean values: PgR/c 5.86 fmol/mg, PgR/n 166 fmol/mg, ER/c 0.76 fmol/mg, ER/n 1.65. It was concluded that direct correlation between estrogen power and progesterone receptor re-plenishment in the nucleus exists.