IMR Press / CEOG / Volume 14 / Issue 3-4 / pii/1634257549256-1956929548

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 47 Issue 1 (2020). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Case Report
Advantage of desogestrel containing pill in oral contraception: influence on blood lipids and lcat activity
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1 Department of Obstetrics and Gynecology - University of Ferrara (Italy)
1 Department of Biochemistry - University of Ferrara (Italy)
Clin. Exp. Obstet. Gynecol. 1987, 14(3-4), 136–139;
Published: 10 September 1987
Abstract

In the present study the effects of a combined oral contraceptive preparation con-taining 0.150 mg desogestrel and 0.030 mg ethinylestradiol on lipid metabolism were investigated. In particular, we observed significant increase in HDL-cholesterol and apolipoprotein-A-I (apo A-I) and B (apo B). Triglycerides were not significantly modified. The cholesterol esteri-fying enzyme LCAT, assayed under “maximal” conditions against an exogenous substrate, was significantly decreased despite an increase. in the physiological stimulator apo A-I. No changes were observed in the anti-atherogenic indexes apo A-I/apo B and HDL-cholesterol/LDL -cho-lesterol. Thus, it appears that this combined oral contraceptive has the promising ability to increase the anti-atherogenic HDL-cholesterol particle without altering the atherogenic LDL-cholesterol.
Keywords
Oral contraceptives
Desogestrel
HDL-cholesterol
LCAT
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