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Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 47 Issue 1 (2020). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.
Case Report
Dose response relationship of relaxin on the pubic ligament of the mouse
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1
Department of Obstetrics and Gynecology
1
University of Tuebingen (Federal Republic of Germany)
2
Department of Physiological Chemistry University of Tuebingen (Federal Republic of Germany)
3
Department of Pharmacology - University of Tuebingen (Federal Republic of Germany)
Clin. Exp. Obstet. Gynecol. 1987, 14(2), 80–83;
Published: 10 June 1987
Abstract
In the present work, the dose-response relationship of highly purified porcine relaxin has been examined on broadening of the pubic ligament in mice. Using the method of Steinetz et al. with 7 days of oestriol priming, higher sensitivity of the pubic ligament was attained in mice with an original weight of 10 g than in those with a weight of 20 g. S-shaped curves were obtained; by increasing the relaxin doses after maximal effect had been reached a decreased action was observed. With presomen priming, a relaxin effect was established after only 2 days instead of the usual 8 days but the action was markedly less than in the Steinetz test.