IMR Press / CEOG / Volume 12 / Issue 3-4 / pii/1634257758048-1873014494

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 47 Issue 1 (2020). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Original Research
Dilemmas in intrauterine fetal growth retardation
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1 Institute of Obstet. Gynec. Clinic, University of Pisa (Italy)
2 Endocrine Unit of the CNR, 1st Medical Clinic, University of Pisa (Italy)
3 Farmigea Research Laboratories, Pisa (Italy)
Clin. Exp. Obstet. Gynecol. 1985, 12(3-4), 93–95;
Published: 10 September 1985

The Authors studied the behaviour of anticomplement and heparin-like activities in human term placentas in relation to intrauterine fetal growth retardation. These two biological activities might be involved in regulatory mechanisms of great importance for the fetal growth. The anticomplement activity was significantly lower in IUGR placentas than in controls, while no change was found in heparin-like activity. The decrease of anticomplement activity might be associated to immunological mechanisms, possibly related to a placental microcirculation damage, with consequent fetal growth retardation. For what concerns HCS and E3 plasma levels during pregnancy, a significant reduction of HCS in IUGR subjects was observed, confirming a decreased functional activity of placenta. The E3 levels, on the contrary, were slightly, but not significantly lower in IUGR patients.
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