The Roles of Genetic and Epigenetic Mechanisms Underlying Cancer Stem Cells

Dear Colleagues,

This special issue seeks to dive deep into the dynamic genetic and epigenetic mechanism responsible for the remarkable traits displayed by cancer stem cells (CSCs).  These traits control proliferative immortality, morphological metamorphosis, and therapeutic resistance. We will explore the molecular underpinnings of CSC activity across a broad spectrum of cancers, and call for scholarly articles that illuminate the intricate processes of genetic regulation, such as DNA and histone modification patterns, the roles of regulatory non-coding RNAs, and transformative events in chromatin architecture that sculpt CSC behavior. This special issue is particularly interested in studies that reveal genetic and epigenetic control over CSC proliferation, mechanisms of intra-tumoral diversity, and response to a variety of pharmacological interventions. This issue also seeks insight on the design of novel therapeutic approaches that specifically target CSC and have great promise in improving the standard of care for cancer as well as addressing the ongoing challenge of tumor persistence. We especially encourage the submission of manuscripts that serve to expand our grasp of regulatory mechanisms controlling CSC function, but also seek to forge a link between basic molecular function and their translational potential in cancer treatment.

Dr. Peixin Dong
Guest Editor

Manuscripts should be submitted via our online editorial system at https://imr.propub.com by registering and logging in to this website. Once you are registered, click here to start your submission. Manuscripts can be submitted now or up until the deadline. All papers will go through peer-review process. Accepted papers will be published in the journal (as soon as accepted) and meanwhile listed together on the special issue website. Research articles, reviews as well as short communications are preferred. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office to announce on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts will be thoroughly refereed through a double-blind peer-review process. Please visit the Instruction for Authors page before submitting a manuscript. The Article Processing Charge (APC) in this open access journal is 2500 USD. Submitted manuscripts should be well formatted in good English.